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  • Writer's pictureRachel Rubin

The Magic of Hormones

I believe the only true essential oil out there is vaginal estrogen. I bet you haven’t heard that one before. In fact, I think at age 45 every woman should go to her doctor and get at the very least 3 prescriptions.

  1. Colonoscopy

  2. Mammogram

  3. A lifetime prescription for local vaginal estrogen.

Now let me take you through my logic.

When vulva owners are babies they have no hormones in their bodies. Think diaper rash, raw/irritated tissue, and constant leaking into diapers. The vulva is small, there are no labia minora and the opening to the vagina is teeny tiny.

Then puberty hits. GASP. Suddenly hormones are raging, we become irritable and mean to our parents and our bodies change. Like a lot. Included in that change, is a significant change to our genitals. Women grow labia minora, their vaginal openings become pink, stretchy, and lubricating.

The magic of hormones.

But then around age 52 – often before, and sometimes after. The ovaries slowly stop making estrogen, progesterone, and testosterone. And that genital tissue, which is so rich in hormone receptors begins to feel the loss.

That means the tissue goes back to being thin, raw, irritated. The opening narrows or shortens. The tissue dries out and loses the acidity it once had to fight infections. The whole microbiome changes which increases the likelihood of urinary tract infections (UTIs).

Other symptoms include urinary frequency, urinary urgency, pelvic pain, pain with urination, vaginal dryness, and constipation.

This condition is called GSM. Say it with me G-S-M. It stands for genitourinary syndrome of menopause. The lack of hormones after 50 causes significant genital and urinary symptoms. And they don’t magically get better or go away with time. In fact, they just keep getting worse.

But all of this is not only treatable but dare I say it is PREVENTABLE.

If we warned women that this was going to happen, we could stop the changes before they start. Hence why I said it’s the only essential oil and should be given early as prevention. Don’t start watering the garden after all the plants have wilted!

Overwhelming data shows that local vaginal estrogen will prevent recurrent UTIs in peri and post menopausal women and it’s recommended by the American Urological Association (AUA) in their guidelines on recurrent UTI.

Not only will vaginal estrogen decrease recurrent UTIs, but it will improve many lower urinary tract symptoms including frequency, urgency, and painful urination. It will also help improve arousal, lubrication and decrease painful penetration.

The problem is that less than 7% of women with GSM are prescribed vaginal estrogen, and many who get the prescription don’t use it properly, can’t afford it, stop using it, or fear using it because of misinformation around mythical harm and inappropriate FDA boxed warnings.

But the crazy thing about this story is that vaginal estrogen is a local treatment. It’s TOTALLY safe for essentially all women. In fact, there are very few woman >50 who I wouldn’t recommend the use of local vaginal estrogen. Occasionally I need to pick up the phone and talk to her cancer doctor to discuss the fine print.

There is no data. NO DATA. That local vaginal estrogen causes cancer, cardiovascular problems, stroke, dementia or any other issues. In fact, studies with over 18 years of observational show safety. Even studies in women who have gynecologic cancers have no issues using local vaginal estrogens. I prescribe and encourage this therapy in my patients with breast cancer, a family history of breast cancer, and those who are worried about breast cancer.

Let me give you a quick example. When I was pregnant my estrogen level was 3,000pg/ml at the same time my husband’s estrogen level was 25pg/ml. Menopausal women’s estrogen level is <5pg/ml and on vaginal estrogen it stays at <5pg/ml. There are many reasons why a women over 50 might want an estrogen higher than 5pg/ml but that is for another post. My point is local vaginal estrogen does not pose a risk to the amount of estrogen in your bloodstream. How is it going to grow a cancer, cause dementia or give you blood clots? It’s not, and it doesn’t.

All hormones are not the same.

A birth control pill has different risks then an IUD which have VERY different risks from a local vaginal estrogen.

Starting local vaginal hormone therapy is easy to do. There are lots of options including inserts, gels, and rings. It may take up to 2-3 months to get maximal benefit (remember the tissue must heal which takes time) and it will only keep working if you keep using the therapy.

Think to yourself. When can I stop brushing my teeth? When can I stop moisturizing my face? When can I stop wearing my seat belt? Never. The answer is never.

Please talk to your doctor about vaginal hormones. Show them this blog post. Show them the table below for options.


Product Name


Vaginal Cream

17-beta- estradiol cream

Estrace, generic

0.5-1gm daily for 2 weeks then 0.5-1gm 1-3x per week

Conjugated equine estrogens cream


0.5-1gm daily for 2 weeks then 0.5-1gm 1-3x per week

​Vaginal Inserts

Estradiol vaginal tablets

Vagifem®, Yuvafem®

10mcg inserts daily for 2 weeks and then 2x per week

Estradiol soft gel capsules


4, 10 mcg inserts daily for 2 weeks and then 2x per week

DHEA (prasterone) inserts


6.5mg capsules daily

Vaginal Ring

17-beta-estradiol ring


1 ring inserted every 3 months


Ospemifene oral tablets


60mg tablet daily

18,736 views17 comments


May 26

Thank you Rachel. I am in tge UK and this article has given me courage. I am an estrogen positive breast cancer survivor and have been suffering GSM symptoms for years since ending my treatment in 2007.

I have now just started using estrogen cream.😊


Mar 28

What are the risks for people with heightened risk of blood clots due to factor V Leiden?


Mar 14

The magic of hormones lies in their profound influence on virtually every aspect of our physical and emotional well-being. From regulating metabolism and growth to impacting mood and sexuality, hormones play a crucial role in maintaining overall health and vitality. For many individuals, hormone replacement therapy (HRT) medication serves as a transformative tool in managing hormonal imbalances or transitioning, offering relief from symptoms and helping align their bodies with their gender identity. However, it's essential to approach HRT with caution, as improper usage or dosage can lead to adverse effects. Nonetheless, when used under the guidance of healthcare professionals, HRT medication can unlock a world of possibilities, empowering individuals to live authentically and harmoniously with their bodies.


Feb 24

I had breast cancerI had surgery and radiation three years this July will be cancer free but I carry a genetic gene called BRIPI 1 not bracca prone to cancers I’m on letrozole my cancer was estrogen produced type ?? I had complete hysterectomy due to pre cells. So I’m wondering is it safe for me if I was to take estrogen cream ??


Sep 20, 2023

Great article, I laughed my way thru it!

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